C—H Functionalization Induced by the Oxidizing Directing Group

Investigating the Effect of Various Oxidizing Agents on the Surface Functionalization of Microporous Polypropylene Membranes

A direct cross-coupling reaction of electron-deficient alkenes using an oxidizing directing group.

An oxidant-free cross-coupling reaction of electron-deficient alkenes using an inexpensive ruthenium catalyst is reported. With the assistance of the oxidizing directing group CONH(OMe), this protocol provides a mild, straightforward and efficient method for the preparation of valuable 1,3-butadiene skeletons with excellent Z,E selectivities.

The Mechanism by Which Ionic Liquids Enable Shilov-Type CH Activation in an Oxidizing Medium

Organometallics is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Article The Mechanism by Which Ionic Liquids Enable Shilov-Type CH Activation in an Oxidizing Medium Zhitao Xu, Jonas Oxgaard, and William Goddard Organometallics, 2008, 27 (15), 3770-3773 • DOI: 10.1021/om800274f • Publication Date (Web): 16 July 2008 Downloaded from http://pubs.acs....

Directing Remote Meta-C–H Functionalization with Cleavable Auxiliaries

The catalytic functionalization of unreactive C–H bonds is an area of great importance for the design of atom economical approaches to useful organic molecules. However, due to the ubiquity of C–H bonds in organic molecules, achieving perfect site-selectivity along with the incorporation of a broad range of functional groups has been one of the major challenges in the area. In this context, the...

Selective and catalytic arylation of N-phenylpyrrolidine: sp3 C-H bond functionalization in the absence of a directing group.

We herein describe our studies on arylation of N-phenylpyrrolidine, which led to the development of a new transformation for the direct and selective arylation of sp3 C-H bonds in the absence of a directing group. In this method, Ru(H)2(CO)(PCy3)3 4 was used as the catalyst, and preliminary mechanistic studies suggested that Ru(Ph)(I)(CO)(PCy3)2 5 is the key intermediate of the catalytic cycle....